# OnCo record chromosomal-instability (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/chromosomal-instability/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "chromosomal-instability" ;
  schema:name "Chromosomal instability & aneuploidy"@en ;
  schema:description "Most cancers have the wrong number of chromosomes and keep shuffling them at every division. This chaos fuels evolution and drug resistance, but it also stresses the cell and can trigger immune alarms, a double edge that researchers are trying to exploit."@en ;
  schema:url <https://onco.cc/pathways/chromosomal-instability/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Chromosome_instability> ;
  owl:sameAs <http://www.wikidata.org/entity/Q1087752> ;
  schema:citation <https://doi.org/10.1038/nature25432>, <https://cancergrandchallenges.org/teams/edynamic> ;
  onco:tag "mechanism" ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/>, <https://onco.cc/technologies/single-cell-spatial/> ;
  onco:targets <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/egfr/> ;
  onco:institutions <https://onco.cc/institutions/francis-crick/>, <https://onco.cc/institutions/mskcc/>, <https://onco.cc/institutions/stanford/>, <https://onco.cc/institutions/cruk/> ;
  onco:pathways <https://onco.cc/pathways/cgas-sting/>, <https://onco.cc/pathways/p53-cell-cycle/>, <https://onco.cc/pathways/replication-stress/>, <https://onco.cc/pathways/clonal-evolution/> ;
  onco:terms <https://onco.cc/terms/genome-instability-mutation/>, <https://onco.cc/terms/whole-genome-doubling/>, <https://onco.cc/terms/mutational-signature/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-bakhoum-nature/> .