# OnCo record chronos (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/chronos/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "chronos", "NCT03227926" ;
  schema:name "CHRONOS"@en ;
  schema:description "The first trial to let a blood test decide whether to give an EGFR antibody a second time. A third of the patients screened had resistance mutations and were excluded; of those rechallenged, three in ten responded."@en ;
  schema:url <https://onco.cc/trials/chronos/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT03227926>, <https://doi.org/10.1038/s41591-022-01886-0> ;
  onco:status "positive" ;
  onco:phase "2" ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/technologies/monoclonal-antibody/>, <https://onco.cc/technologies/mrd-testing/> ;
  onco:targets <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/kras/>, <https://onco.cc/targets/nras/>, <https://onco.cc/targets/braf/> ;
  onco:drugs <https://onco.cc/drugs/panitumumab/> ;
  onco:terms <https://onco.cc/terms/ctdna/> .