# OnCo record cimp (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/cimp/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "cimp" ;
  schema:name "CpG island methylator phenotype (CIMP)"@en ;
  schema:alternateName "CIMP"@en, "CpG island methylator phenotype"@en, "CIMP-high"@en, "CIMP-low"@en, "hypermethylated colorectal cancer"@en ;
  schema:description "Some bowel cancers switch off large numbers of genes at once by chemically tagging their control regions rather than by mutating them. That state travels with BRAF mutation, with the serrated route to cancer and with the accidental loss of DNA proofreading, and it is how most bowel cancers with unstable microsatellites arise without an inherited fault."@en ;
  schema:url <https://onco.cc/terms/cimp/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/CpG_site> ;
  schema:citation <https://doi.org/10.1073/pnas.96.15.8681>, <https://doi.org/10.1038/ng1834>, <https://doi.org/10.1111/his.12055> ;
  onco:tag "gi", "colorectal" ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/msi-high-colorectal/>, <https://onco.cc/cancers/braf-v600e-colorectal/>, <https://onco.cc/cancers/colorectal-serrated-adenocarcinoma/>, <https://onco.cc/cancers/colon-cancer/> ;
  onco:technologies <https://onco.cc/technologies/msi-mmr-testing/>, <https://onco.cc/technologies/histopathology-ihc/> ;
  onco:targets <https://onco.cc/targets/braf/> ;
  onco:terms <https://onco.cc/terms/serrated-pathway/>, <https://onco.cc/terms/mlh1-promoter-methylation/>, <https://onco.cc/terms/msi/>, <https://onco.cc/terms/lynch-syndrome/>, <https://onco.cc/terms/cms-subtypes/>, <https://onco.cc/terms/sidedness/> .