# OnCo record circulate-us (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/circulate-us/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "circulate-us", "NCT05174169" ;
  schema:name "CIRCULATE-US"@en ;
  schema:alternateName "NRG-GI008"@en, "Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease"@en ;
  schema:description "The US national trial that uses a blood test for leftover tumour DNA to decide who gets less chemotherapy and who gets more after stage III colon cancer surgery, with both questions randomised."@en ;
  schema:url <https://onco.cc/trials/circulate-us/> ;
  schema:dateModified "2026-09-21"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT05174169> ;
  onco:status "recruiting" ;
  onco:tag "ctdna-roadmap" ;
  onco:phase "2/3" ;
  onco:related <https://onco.cc/trials/dynamic/>, <https://onco.cc/trials/circulate-japan/>, <https://onco.cc/trials/tracc/>, <https://onco.cc/pairings/ctdna-mrd-to-adjuvant/>, <https://onco.cc/roadmaps/ctdna-tests/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/mrd-testing/>, <https://onco.cc/technologies/liquid-biopsy/> ;
  onco:drugs <https://onco.cc/drugs/signatera/>, <https://onco.cc/drugs/capox/> ;
  onco:companies <https://onco.cc/institutions/nrg-oncology/>, <https://onco.cc/companies/natera/> ;
  onco:terms <https://onco.cc/terms/mrd/>, <https://onco.cc/terms/ctdna/>, <https://onco.cc/terms/de-escalation/>, <https://onco.cc/terms/tumour-informed-assay/> .