# OnCo record cit-in-del17p-caution (pairing). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pairings/cit-in-del17p-caution/>
  a schema:MedicalTherapy ;
  onco:kind "pairing" ;
  schema:identifier "cit-in-del17p-caution" ;
  schema:name "Caution: chemoimmunotherapy in del(17p)/TP53 CLL"@en ;
  schema:description "Chemotherapy-based regimens barely work when the p53 gene is lost; these patients need BTK inhibitors or venetoclax from the start."@en ;
  schema:url <https://onco.cc/pairings/cit-in-del17p-caution/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT03336333> ;
  onco:cancers <https://onco.cc/cancers/cll/> ;
  onco:drugs <https://onco.cc/drugs/rituximab/>, <https://onco.cc/drugs/zanubrutinib/>, <https://onco.cc/drugs/venetoclax/> ;
  onco:terms <https://onco.cc/terms/del17p-tp53/> ;
  onco:trials <https://onco.cc/trials/sequoia/> ;
  onco:pairs <https://onco.cc/drugs/rituximab/>, <https://onco.cc/terms/del17p-tp53/> .