# OnCo record cll12 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/cll12/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "cll12", "NCT02863718" ;
  schema:name "CLL12"@en ;
  schema:alternateName "GCLLSG CLL12"@en ;
  schema:description "CLL12 asked whether starting the pill ibrutinib early, before chronic lymphocytic leukaemia causes symptoms, is better than the usual practice of watching and waiting; early treatment delayed the disease but after nearly six years of follow-up people lived just as long either way, so watch and wait remains the standard."@en ;
  schema:url <https://onco.cc/trials/cll12/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT02863718> ;
  onco:status "mixed" ;
  onco:tag "soc-trials" ;
  onco:phase "3" ;
  onco:cancers <https://onco.cc/cancers/cll/>, <https://onco.cc/cancers/cll-treatment-naive/>, <https://onco.cc/cancers/leukaemia/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/active-surveillance/> ;
  onco:drugs <https://onco.cc/drugs/ibrutinib/> ;
  onco:companies <https://onco.cc/companies/johnson-johnson/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-cll12-ibrutinib-early-stage-langerbeins-jco-2025/> .