# OnCo record clonal-evolution-models (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/clonal-evolution-models/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "clonal-evolution-models" ;
  schema:name "Clonal evolution and branching models"@en ;
  schema:description "Peter Nowell's 1976 idea that a tumour is an evolving population of competing clones is now measured directly by sequencing several regions or repeated blood samples, and models of branching evolution predict which clones will drive relapse."@en ;
  schema:url <https://onco.cc/technologies/clonal-evolution-models/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://doi.org/10.1126/science.959840>, <https://doi.org/10.1056/NEJMoa1616288> ;
  onco:status "established" ;
  onco:tag "mathematical-model" ;
  onco:cancers <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/rcc/> ;
  onco:sections <https://onco.cc/fronts/ai-computation/>, <https://onco.cc/fronts/drug-discovery/> ;
  onco:technologies <https://onco.cc/technologies/clonal-evolution-tracking/>, <https://onco.cc/technologies/continuous-ctdna-monitoring/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-nowell-science/> .