# OnCo record clonal-evolution-theory (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/clonal-evolution-theory/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "clonal-evolution-theory" ;
  schema:name "Clonal evolution and the ecological view of cancer"@en ;
  schema:alternateName "clonal evolution theory"@en, "evolutionary theory of cancer"@en, "cancer as an evolutionary process"@en, "ecological view of cancer"@en, "Darwinian model of cancer"@en, "branched evolution"@en ;
  schema:description "A tumour is a population of cells that mutate, compete and are selected, exactly as species are, and treatment is one more selective pressure. Peter Nowell proposed this in 1976; it explains why tumours are mixtures of clones, why resistance to almost any single drug appears, and why some researchers now try to steer a tumour's evolution rather than eradicate it."@en ;
  schema:url <https://onco.cc/terms/clonal-evolution-theory/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Somatic_evolution_in_cancer> ;
  schema:citation <https://doi.org/10.1126/science.959840>, <https://doi.org/10.1038/nrc2013>, <https://doi.org/10.1038/nature10762>, <https://doi.org/10.1056/NEJMoa1113205>, <https://doi.org/10.1158/0008-5472.CAN-08-3658>, <https://doi.org/10.1038/s41467-017-01968-5>, <https://doi.org/10.1038/ng.3214> ;
  onco:tag "theory" ;
  onco:related <https://onco.cc/pathways/theories-of-cancer/>, <https://onco.cc/terms/somatic-mutation-theory/>, <https://onco.cc/terms/driver-passenger-model/>, <https://onco.cc/terms/ageing-tissue-field-theory/>, <https://onco.cc/terms/immune-surveillance-immunoediting/>, <https://onco.cc/terms/aneuploidy-theory-of-cancer/>, <https://onco.cc/terms/cancer-stem-cell-theory/>, <https://onco.cc/pathways/clonal-evolution/>, <https://onco.cc/technologies/clonal-evolution-models/>, <https://onco.cc/technologies/adaptive-therapy-dynamics/>, <https://onco.cc/technologies/evolutionary-game-theory-cancer/>, <https://onco.cc/technologies/mathematical-oncology/>, <https://onco.cc/pathways/drug-tolerant-persisters/>, <https://onco.cc/pathways/field-cancerisation/>, <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/mrd/>, <https://onco.cc/terms/ctdna/> ;
  onco:cancers <https://onco.cc/cancers/cml/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/prostate/> ;
  onco:technologies <https://onco.cc/technologies/mrd-testing/>, <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/technologies/wes-wgs/>, <https://onco.cc/technologies/adaptive-therapy-dynamics/>, <https://onco.cc/technologies/clonal-evolution-models/>, <https://onco.cc/technologies/evolutionary-game-theory-cancer/> ;
  onco:pathways <https://onco.cc/pathways/clonal-evolution/>, <https://onco.cc/pathways/drug-tolerant-persisters/>, <https://onco.cc/pathways/field-cancerisation/>, <https://onco.cc/pathways/resistance-routes-map/> ;
  onco:people <https://onco.cc/people/mel-greaves/>, <https://onco.cc/people/robert-gatenby/>, <https://onco.cc/people/charles-swanton/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-gerlinger-intratumour-heterogeneity-nejm-2012/>, <https://onco.cc/key-papers/paper-zhang-nat-commun/>, <https://onco.cc/key-papers/paper-greaves-nature/>, <https://onco.cc/key-papers/paper-nowell-science/>, <https://onco.cc/key-papers/paper-gatenby-cancer-res/>, <https://onco.cc/key-papers/paper-sottoriva-nat-genet/>, <https://onco.cc/key-papers/paper-merlo-nat-rev-cancer/> .