# OnCo record clonal-evolution (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/clonal-evolution/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "clonal-evolution" ;
  schema:name "Clonal evolution & minimal residual disease"@en ;
  schema:description "A tumour is a population that evolves by natural selection. Treatment kills the sensitive cells and selects the rest, which is why resistance is the rule; measuring the surviving population (MRD) and adapting therapy is the counter-strategy."@en ;
  schema:url <https://onco.cc/pathways/clonal-evolution/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Somatic_evolution_in_cancer> ;
  owl:sameAs <http://www.wikidata.org/entity/Q7559241> ;
  schema:citation <https://doi.org/10.1056/NEJMoa1616288>, <https://doi.org/10.1038/s41467-017-01968-5> ;
  onco:tag "mechanism" ;
  onco:related <https://onco.cc/pathways/theories-of-cancer/>, <https://onco.cc/terms/clonal-evolution-theory/> ;
  onco:technologies <https://onco.cc/technologies/mrd-testing/>, <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/technologies/wes-wgs/> ;
  onco:institutions <https://onco.cc/institutions/francis-crick/>, <https://onco.cc/institutions/moffitt/>, <https://onco.cc/institutions/broad-institute/>, <https://onco.cc/institutions/mskcc/> ;
  onco:pathways <https://onco.cc/pathways/chromosomal-instability/>, <https://onco.cc/pathways/metastatic-cascade/>, <https://onco.cc/pathways/tumor-dormancy/> ;
  onco:terms <https://onco.cc/terms/mrd/>, <https://onco.cc/terms/ctdna/>, <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/vaf/>, <https://onco.cc/terms/mutational-signature/> ;
  onco:trials <https://onco.cc/trials/imvigor011/>, <https://onco.cc/trials/dynamic/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-zhang-nat-commun/> .