# OnCo record clonal-haematopoiesis (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/clonal-haematopoiesis/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "clonal-haematopoiesis" ;
  schema:name "Clonal haematopoiesis (CHIP)"@en ;
  schema:description "As we age, blood stem cells with cancer-like mutations quietly expand in most people. These clones raise leukaemia and heart disease risk, are accelerated by chemotherapy, and confuse blood tests for cancer DNA."@en ;
  schema:url <https://onco.cc/pathways/clonal-haematopoiesis/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Clonal_hematopoiesis> ;
  owl:sameAs <http://www.wikidata.org/entity/Q30314746> ;
  schema:citation <https://doi.org/10.1056/NEJMoa1408617>, <https://doi.org/10.1038/s41588-020-00710-0> ;
  onco:tag "mechanism" ;
  onco:related <https://onco.cc/terms/ageing-tissue-field-theory/> ;
  onco:cancers <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-mcrpc/> ;
  onco:technologies <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/technologies/mrd-testing/>, <https://onco.cc/technologies/parp-inhibitor/> ;
  onco:targets <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/parp/>, <https://onco.cc/targets/tet2/> ;
  onco:institutions <https://onco.cc/institutions/dana-farber/>, <https://onco.cc/institutions/broad-institute/>, <https://onco.cc/institutions/mskcc/> ;
  onco:pathways <https://onco.cc/pathways/clonal-evolution/>, <https://onco.cc/pathways/inflammation-nfkb/>, <https://onco.cc/pathways/epigenetic-reprogramming/> ;
  onco:terms <https://onco.cc/terms/vaf/>, <https://onco.cc/terms/ctdna/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-jensen-clonal-haematopoiesis-cfdna-interference-prostate-jama-oncol-2021/>, <https://onco.cc/key-papers/paper-tukachinsky-ctdna-3334-advanced-prostate-ccr-2021/>, <https://onco.cc/key-papers/paper-bolton-nat-genet/> .