# OnCo record cns-penetration (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/cns-penetration/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "cns-penetration" ;
  schema:name "CNS penetration (brain-penetrant drugs)"@en ;
  schema:alternateName "CNS penetration"@en, "CNS-penetrant"@en, "CNS penetrant"@en, "brain-penetrant"@en, "brain penetrant"@en, "brain penetration"@en, "blood-brain barrier penetration"@en, "BBB-penetrant"@en, "CNS-active"@en, "intracranial efficacy"@en, "CNS efficacy"@en, "CNS progression"@en, "CNS protection"@en, "CSF concentration"@en, "Kp,uu"@en, "efflux transporter"@en, "P-glycoprotein substrate"@en, "efflux transporters"@en ;
  schema:description "How well a drug crosses from the blood into the brain, where most cancer drugs are kept out by the blood-brain barrier. Brain-penetrant pills can treat and prevent brain metastases; those that are not leave the brain as a sanctuary where the cancer regrows."@en ;
  schema:url <https://onco.cc/terms/cns-penetration/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Blood%E2%80%93brain_barrier> ;
  schema:citation <https://en.wikipedia.org/wiki/Blood%E2%80%93brain_barrier> ;
  onco:related <https://onco.cc/terms/brain-metastases/>, <https://onco.cc/terms/leptomeningeal-disease/>, <https://onco.cc/terms/intrathecal-therapy/>, <https://onco.cc/terms/tki-term/> ;
  onco:sections <https://onco.cc/fronts/targeted-therapy/> ;
  onco:drugs <https://onco.cc/drugs/osimertinib/>, <https://onco.cc/drugs/tucatinib/>, <https://onco.cc/drugs/trastuzumab-deruxtecan/>, <https://onco.cc/drugs/temozolomide/> .