# OnCo record cobrim (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/cobrim/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "cobrim", "NCT01689519" ;
  schema:name "coBRIM"@en ;
  schema:description "coBRIM showed that adding cobimetinib to vemurafenib gives people with BRAF-mutant melanoma about five more months before the disease grows and about five more months of life."@en ;
  schema:url <https://onco.cc/trials/cobrim/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT01689519>, <https://www.nejm.org/doi/full/10.1056/NEJMoa1408868>, <https://doi.org/10.1016/S1470-2045(16)30122-X> ;
  onco:status "positive" ;
  onco:phase "3" ;
  onco:cancers <https://onco.cc/cancers/braf-v600-melanoma/>, <https://onco.cc/cancers/advanced-melanoma/>, <https://onco.cc/cancers/melanoma/> ;
  onco:targets <https://onco.cc/targets/braf/>, <https://onco.cc/targets/mek/> ;
  onco:drugs <https://onco.cc/drugs/vemurafenib/>, <https://onco.cc/drugs/cobimetinib/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/> ;
  onco:people <https://onco.cc/people/james-larkin/>, <https://onco.cc/people/paolo-ascierto/> .