# OnCo record codebreak-300 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/codebreak-300/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "codebreak-300", "NCT05198934" ;
  schema:name "CodeBreaK 300"@en ;
  schema:description "CodeBreaK 300 showed that a KRAS drug needs an EGFR antibody partner to work in colorectal cancer."@en ;
  schema:url <https://onco.cc/trials/codebreak-300/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT05198934> ;
  onco:status "positive" ;
  onco:phase "3" ;
  schema:startDate "2022-04-19" ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/kras-g12c-colorectal/> ;
  onco:technologies <https://onco.cc/technologies/kras-inhibitors/> ;
  onco:targets <https://onco.cc/targets/kras/>, <https://onco.cc/targets/egfr/> ;
  onco:drugs <https://onco.cc/drugs/sotorasib/> ;
  onco:companies <https://onco.cc/companies/amgen/> ;
  onco:trials <https://onco.cc/trials/nct06252649/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-codebreak-300-nejm-2023/>, <https://onco.cc/key-papers/paper-schirripa-kras-g12c-metastatic-colorectal-clin-colorectal-cancer-2020/> .