# OnCo record coin (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/coin/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "coin", "ISRCTN27286448" ;
  schema:name "MRC COIN"@en ;
  schema:alternateName "COIN"@en, "ISRCTN27286448"@en ;
  schema:description "The UK trial that checked whether adding an antibody to first-line chemotherapy for advanced bowel cancer helps people live longer, and found it does not."@en ;
  schema:url <https://onco.cc/trials/coin/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://europepmc.org/article/MED/21641636>, <https://www.isrctn.com/ISRCTN27286448> ;
  onco:status "negative" ;
  onco:tag "uk", "colorectal", "anti-egfr" ;
  onco:phase "3" ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:sections <https://onco.cc/fronts/chemotherapy/> ;
  onco:targets <https://onco.cc/targets/kras/>, <https://onco.cc/targets/egfr/> ;
  onco:drugs <https://onco.cc/drugs/cetuximab/>, <https://onco.cc/drugs/folfox/>, <https://onco.cc/drugs/capox/>, <https://onco.cc/drugs/oxaliplatin/> ;
  onco:institutions <https://onco.cc/institutions/oxford-cancer/>, <https://onco.cc/institutions/velindre-cardiff/> ;
  onco:people <https://onco.cc/people/tim-maughan/> .