# OnCo record combi-ad (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/combi-ad/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "combi-ad", "NCT01682083" ;
  schema:name "COMBI-AD"@en ;
  schema:description "A year of two targeted pills after surgery halves the risk of relapse in BRAF-mutant melanoma, and the benefit is still visible a decade later."@en ;
  schema:url <https://onco.cc/trials/combi-ad/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT01682083>, <https://ascopubs.org/doi/10.1200/JCO.2024.42.16_suppl.9500> ;
  onco:status "positive" ;
  onco:phase "3" ;
  schema:startDate "2013-01-08" ;
  onco:cancers <https://onco.cc/cancers/melanoma/>, <https://onco.cc/cancers/braf-v600-melanoma/>, <https://onco.cc/cancers/stage-iii-melanoma/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/braf/> ;
  onco:drugs <https://onco.cc/drugs/dabrafenib-trametinib/> ;
  onco:companies <https://onco.cc/companies/novartis/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/> ;
  onco:people <https://onco.cc/people/georgina-long/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-combi-ad-nejm-2017/>, <https://onco.cc/key-papers/paper-combi-ad-n-engl-j-med-2020-update/> .