# OnCo record combomatch-binimetinib-folfox (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/combomatch-binimetinib-folfox/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "combomatch-binimetinib-folfox", "NCT05564403" ;
  schema:name "ComboMATCH: FOLFOX with or without binimetinib in second-line biliary tract cancer with MAPK pathway alterations"@en ;
  schema:alternateName "ComboMATCH biliary"@en ;
  schema:description "Part of the American ComboMATCH precision-medicine programme, this trial adds the MEK inhibitor binimetinib to FOLFOX for people whose bile duct or gallbladder cancer carries a KRAS or related pathway mutation, the most common gallbladder cancer drivers."@en ;
  schema:url <https://onco.cc/trials/combomatch-binimetinib-folfox/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT05564403> ;
  onco:status "active" ;
  onco:phase "2" ;
  onco:cancers <https://onco.cc/cancers/gallbladder/>, <https://onco.cc/cancers/cholangiocarcinoma/>, <https://onco.cc/cancers/intrahepatic-cholangiocarcinoma/>, <https://onco.cc/cancers/extrahepatic-cholangiocarcinoma/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/platinum/> ;
  onco:targets <https://onco.cc/targets/kras/> ;
  onco:drugs <https://onco.cc/drugs/binimetinib/>, <https://onco.cc/drugs/folfox/>, <https://onco.cc/drugs/fluorouracil/>, <https://onco.cc/drugs/oxaliplatin/>, <https://onco.cc/drugs/leucovorin/> ;
  onco:terms <https://onco.cc/terms/basket-umbrella-platform/> .