# OnCo record comfort-i (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/comfort-i/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "comfort-i", "NCT00952289" ;
  schema:name "COMFORT-I"@en ;
  schema:alternateName "COMFORT"@en, "INCB 18424-351"@en ;
  schema:description "COMFORT-I showed that the JAK-blocking pill ruxolitinib shrank the grossly enlarged spleens of people with myelofibrosis in about four in ten patients, against almost none on placebo, and eased their fatigue, night sweats and itching; it led to the first approved drug for the disease."@en ;
  schema:url <https://onco.cc/trials/comfort-i/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT00952289> ;
  onco:status "positive" ;
  onco:tag "soc-trials" ;
  onco:phase "3" ;
  onco:cancers <https://onco.cc/cancers/primary-myelofibrosis/>, <https://onco.cc/cancers/myeloproliferative-neoplasms/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:drugs <https://onco.cc/drugs/ruxolitinib/> ;
  onco:companies <https://onco.cc/companies/incyte/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-comfort-1-ruxolitinib-myelofibrosis-nejm-2012/> .