# OnCo record complement-in-cancer (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/complement-in-cancer/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "complement-in-cancer" ;
  schema:name "Complement in cancer"@en ;
  schema:description "Complement is a cascade of blood proteins that punches holes in things marked by antibodies and calls in inflammatory cells. Therapeutic antibodies such as rituximab use it to kill cancer cells; tumours defend themselves with shields (CD46, CD55, CD59), and the cascade's own by-products (C5a) can recruit the myeloid cells that protect the tumour."@en ;
  schema:url <https://onco.cc/pathways/complement-in-cancer/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Complement_system> ;
  schema:citation <https://doi.org/10.1038/s41568-019-0210-0> ;
  onco:tag "mechanism", "mechanics-atlas" ;
  onco:cancers <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/follicular-lymphoma/>, <https://onco.cc/cancers/cll/>, <https://onco.cc/cancers/multiple-myeloma/> ;
  onco:technologies <https://onco.cc/technologies/monoclonal-antibody/>, <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:targets <https://onco.cc/targets/cd20/>, <https://onco.cc/targets/cd38/>, <https://onco.cc/targets/cd19/>, <https://onco.cc/targets/pd1/>, <https://onco.cc/targets/csf1r/> ;
  onco:drugs <https://onco.cc/drugs/rituximab/>, <https://onco.cc/drugs/obinutuzumab/>, <https://onco.cc/drugs/daratumumab/>, <https://onco.cc/drugs/isatuximab/> ;
  onco:pathways <https://onco.cc/pathways/myeloid-suppression-axis/>, <https://onco.cc/pathways/inflammation-nfkb/>, <https://onco.cc/pathways/nk-cell-recognition/>, <https://onco.cc/pathways/extrinsic-apoptosis-death-receptors/> ;
  onco:terms <https://onco.cc/terms/adcc/>, <https://onco.cc/terms/fc-effector/>, <https://onco.cc/terms/crs/>, <https://onco.cc/terms/myeloid-derived-suppressor-cells/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-roumenina-nat-rev-cancer/> .