# OnCo record crystal-fire3 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/crystal-fire3/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "crystal-fire3", "NCT00154102" ;
  schema:name "CRYSTAL & FIRE-3"@en ;
  schema:alternateName "CRYSTAL"@en, "FIRE-3"@en, "CRYSTAL and FIRE-3"@en ;
  schema:description "The trials that established EGFR antibodies in bowel cancer and discovered they only work when the RAS gene is normal."@en ;
  schema:url <https://onco.cc/trials/crystal-fire3/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://www.nejm.org/doi/full/10.1056/NEJMoa0805019>, <https://clinicaltrials.gov/study/NCT00154102>, <https://clinicaltrials.gov/study/NCT00433927>, <https://doi.org/10.1056/NEJMoa0805019>, <https://doi.org/10.1016/S1470-2045(14)70330-4> ;
  onco:status "positive" ;
  onco:phase "3" ;
  schema:startDate "2004-05" ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/monoclonal-antibody/> ;
  onco:targets <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/kras/> ;
  onco:drugs <https://onco.cc/drugs/cetuximab/>, <https://onco.cc/drugs/bevacizumab/>, <https://onco.cc/drugs/folfiri/> ;
  onco:companies <https://onco.cc/companies/aio/> ;
  onco:terms <https://onco.cc/terms/sidedness/> ;
  onco:trials <https://onco.cc/trials/prime/>, <https://onco.cc/trials/opus/>, <https://onco.cc/trials/calgb-80405/> ;
  onco:people <https://onco.cc/people/volker-heinemann/>, <https://onco.cc/people/eric-van-cutsem/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-tejpar-tumour-location-crystal-fire3-jama-oncol-2017/>, <https://onco.cc/key-papers/paper-arnold-primary-tumour-side-ras-wild-type-ann-oncol-2017/> .