# OnCo record ctla4 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/ctla4/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "ctla4" ;
  schema:name "CTLA-4"@en ;
  schema:description "The first immune brake ever targeted for cancer; releasing it won a Nobel Prize and cures a fraction of melanomas."@en ;
  schema:url <https://onco.cc/targets/ctla4/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/CTLA-4>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2505>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163599>, <https://www.uniprot.org/uniprotkb/P16410/entry>, <https://www.ncbi.nlm.nih.gov/gene/1493> ;
  schema:citation <https://en.wikipedia.org/wiki/CTLA-4> ;
  onco:tag "checkpoint" ;
  schema:alternateName "CTLA4" ;
  onco:targetClass "checkpoint" ;
  onco:firstDescribed "1988"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/melanoma/>, <https://onco.cc/cancers/rcc/>, <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/hcc/>, <https://onco.cc/cancers/mesothelioma/> ;
  onco:drugs <https://onco.cc/drugs/gotistobart/>, <https://onco.cc/drugs/bcd-217/>, <https://onco.cc/drugs/adg126/>, <https://onco.cc/drugs/botensilimab/>, <https://onco.cc/drugs/jk08/>, <https://onco.cc/drugs/lorigerlimab/>, <https://onco.cc/drugs/ba3071/> ;
  onco:companies <https://onco.cc/companies/xilio-therapeutics/> ;
  onco:pathways <https://onco.cc/pathways/pd1-checkpoint/> .