# OnCo record cupisco (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/cupisco/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "cupisco", "NCT03498521" ;
  schema:name "CUPISCO"@en ;
  schema:alternateName "CUPISCO trial"@en ;
  schema:description "CUPISCO was the first randomised test of precision medicine in cancer of unknown primary, where doctors cannot see where the cancer started. After three rounds of chemotherapy, switching to a drug chosen from the tumour's genetic profile held the cancer back for longer than carrying on with chemotherapy."@en ;
  schema:url <https://onco.cc/trials/cupisco/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT03498521>, <https://doi.org/10.1016/S0140-6736(24)00814-6> ;
  onco:status "positive" ;
  onco:phase "2" ;
  schema:startDate "2018-07-10" ;
  onco:cancers <https://onco.cc/cancers/cancer-of-unknown-primary/>, <https://onco.cc/cancers/cup-unfavourable/> ;
  onco:technologies <https://onco.cc/technologies/cgp/>, <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/parp-inhibitor/> ;
  onco:drugs <https://onco.cc/drugs/atezolizumab/>, <https://onco.cc/drugs/alectinib/>, <https://onco.cc/drugs/entrectinib/>, <https://onco.cc/drugs/erlotinib/>, <https://onco.cc/drugs/vemurafenib/>, <https://onco.cc/drugs/cobimetinib/>, <https://onco.cc/drugs/vismodegib/>, <https://onco.cc/drugs/trastuzumab-emtansine/>, <https://onco.cc/drugs/pertuzumab/>, <https://onco.cc/drugs/trastuzumab/>, <https://onco.cc/drugs/olaparib/>, <https://onco.cc/drugs/ipatasertib/>, <https://onco.cc/drugs/carboplatin/>, <https://onco.cc/drugs/cisplatin/>, <https://onco.cc/drugs/paclitaxel/>, <https://onco.cc/drugs/gemcitabine/> ;
  onco:companies <https://onco.cc/companies/roche-genentech/>, <https://onco.cc/companies/foundation-medicine/> ;
  onco:terms <https://onco.cc/terms/master-protocol/>, <https://onco.cc/terms/basket-umbrella-platform/>, <https://onco.cc/terms/pfs/> ;
  onco:people <https://onco.cc/people/linda-mileshkin/> .