# OnCo record cyp11a1 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/cyp11a1/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "cyp11a1" ;
  schema:name "CYP11A1 (cholesterol side-chain cleavage enzyme)"@en ;
  schema:description "CYP11A1 is the first enzyme in making every steroid hormone from cholesterol; the historic breast cancer drug aminoglutethimide blocked it, cutting oestrogen and adrenal steroids, before aromatase inhibitors made that approach precise."@en ;
  schema:url <https://onco.cc/targets/cyp11a1/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Cholesterol_side-chain_cleavage_enzyme>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2590>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000140459>, <https://www.uniprot.org/uniprotkb/P05108/entry>, <https://www.ncbi.nlm.nih.gov/gene/1583> ;
  schema:citation <https://www.uniprot.org/uniprotkb/P05108/entry>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2590>, <https://www.ebi.ac.uk/chembl/explore/target/CHEMBL2033> ;
  onco:tag "chembl-gap" ;
  schema:alternateName "CYP11A1" ;
  onco:targetClass "enzyme" ;
  onco:firstDescribed "1986"^^xsd:gYear ;
  onco:related <https://onco.cc/targets/cyp17a1/>, <https://onco.cc/targets/aromatase/> ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/prostate/> ;
  onco:drugs <https://onco.cc/drugs/aminoglutethimide/> .