# OnCo record cyp17a1 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/cyp17a1/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "cyp17a1" ;
  schema:name "CYP17A1 (17-alpha-hydroxylase/17,20-lyase)"@en ;
  schema:description "The enzyme that makes androgens in the testes, the adrenal glands and prostate tumours themselves. Abiraterone blocks it, cutting androgen production below what castration alone achieves."@en ;
  schema:url <https://onco.cc/targets/cyp17a1/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/CYP17A1>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2593>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000148795>, <https://www.uniprot.org/uniprotkb/P05093/entry>, <https://www.ncbi.nlm.nih.gov/gene/1586> ;
  schema:citation <https://www.uniprot.org/uniprotkb/P05093/entry> ;
  schema:alternateName "CYP17A1" ;
  onco:targetClass "enzyme" ;
  onco:firstDescribed "1987"^^xsd:gYear ;
  onco:related <https://onco.cc/targets/androgen-receptor/> ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-mcrpc/> ;
  onco:drugs <https://onco.cc/drugs/abiraterone/> ;
  onco:terms <https://onco.cc/terms/castration-resistance/>, <https://onco.cc/terms/mcrpc-mhspc/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-taplin-ar-mutation-androgen-independent-prostate-nejm-1995/> .