# OnCo record cytotoxic-chemotherapy (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/cytotoxic-chemotherapy/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "cytotoxic-chemotherapy" ;
  schema:name "Cytotoxic chemotherapy"@en ;
  schema:description "Cytotoxic chemotherapy drugs (platinums, antimetabolites, microtubule agents and topoisomerase inhibitors) kill rapidly dividing cells by damaging DNA or the mitotic spindle. They still cure testicular cancer, lymphoma and leukaemia, and they are the warhead inside antibody-drug conjugates, but a narrow margin between effective and toxic doses is their limitation."@en ;
  schema:url <https://onco.cc/technologies/cytotoxic-chemotherapy/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Chemotherapy> ;
  owl:sameAs <http://www.wikidata.org/entity/Q974135> ;
  schema:citation <https://en.wikipedia.org/wiki/Chemotherapy> ;
  onco:status "standard-of-care" ;
  onco:related <https://onco.cc/pairings/genomic-assay-to-chemo-omission/>, <https://onco.cc/technologies/body-surface-area-dosing/>, <https://onco.cc/technologies/log-kill-hypothesis/> ;
  onco:sections <https://onco.cc/fronts/chemotherapy/> ;
  onco:drugs <https://onco.cc/drugs/raltitrexed/>, <https://onco.cc/drugs/vindesine/>, <https://onco.cc/drugs/alitretinoin/>, <https://onco.cc/drugs/estramustine/>, <https://onco.cc/drugs/floxuridine/>, <https://onco.cc/drugs/streptozocin/>, <https://onco.cc/drugs/teniposide/>, <https://onco.cc/drugs/altretamine/>, <https://onco.cc/drugs/plicamycin/>, <https://onco.cc/drugs/amsacrine/>, <https://onco.cc/drugs/uracil-mustard/>, <https://onco.cc/drugs/mitobronitol/>, <https://onco.cc/drugs/pipobroman/>, <https://onco.cc/drugs/doxifluridine/>, <https://onco.cc/drugs/plitidepsin/> ;
  onco:companies <https://onco.cc/companies/lupin/>, <https://onco.cc/companies/intas/>, <https://onco.cc/companies/shasqi/>, <https://onco.cc/companies/telik/>, <https://onco.cc/companies/vion-pharmaceuticals/> ;
  onco:terms <https://onco.cc/terms/efflux-pump/> ;
  onco:trials <https://onco.cc/trials/euramos-1/>, <https://onco.cc/trials/gefitinib-chemo-tmh/> ;
  onco:journals <https://onco.cc/journals/cancer-chemotherapy-and-pharmacology/>, <https://onco.cc/journals/gan-to-kagaku-ryoho/> .