# OnCo record dactinomycin (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/dactinomycin/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "dactinomycin" ;
  schema:name "Dactinomycin (actinomycin D)"@en ;
  schema:alternateName "Actinomycin D"@en, "Actinomycin"@en, "Cosmegen" ;
  schema:description "The first antibiotic used as an anticancer drug (1954) and still the core of chemotherapy for Wilms tumour, rhabdomyosarcoma and gestational trophoblastic disease."@en ;
  schema:url <https://onco.cc/drugs/dactinomycin/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Dactinomycin> ;
  owl:sameAs <http://www.wikidata.org/entity/Q186127> ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=dactinomycin> ;
  onco:status "approved" ;
  onco:tag "gap-fill", "generic", "who-essential" ;
  onco:modality "Actinomycin antibiotic (transcription inhibitor)" ;
  onco:approval "US 1964: Wilms tumour, rhabdomyosarcoma, Ewing sarcoma, gestational trophoblastic neoplasia, metastatic testicular cancer, regional perfusion for sarcoma" ;
  onco:cancers <https://onco.cc/cancers/wilms-tumor/>, <https://onco.cc/cancers/rhabdomyosarcoma/>, <https://onco.cc/cancers/gestational-trophoblastic/>, <https://onco.cc/cancers/ewing-sarcoma/>, <https://onco.cc/cancers/testicular/>, <https://onco.cc/cancers/low-risk-gtn/>, <https://onco.cc/cancers/high-risk-gtn/> ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/isolated-limb-perfusion/> ;
  onco:companies <https://onco.cc/companies/recordati/>, <https://onco.cc/companies/nobelpharma/> ;
  onco:terms <https://onco.cc/terms/re-irradiation/> .