# OnCo record darolutamide (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/darolutamide/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "darolutamide" ;
  schema:name "Darolutamide"@en ;
  schema:description "Darolutamide is an AR blocker that barely enters the brain, so it causes fewer falls and cognitive side effects; it is approved with and without chemotherapy."@en ;
  schema:url <https://onco.cc/drugs/darolutamide/> ;
  schema:dateModified "2026-09-06"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Darolutamide> ;
  owl:sameAs <http://www.wikidata.org/entity/Q25091391> ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Darolutamide>, <https://www.nice.org.uk/guidance/ta660>, <https://www.nice.org.uk/guidance/ta903>, <https://www.nice.org.uk/guidance/ta1109> ;
  onco:status "approved" ;
  onco:modality "Small-molecule AR antagonist" ;
  schema:alternateName "Nubeqa" ;
  onco:approval "US 2019: Non-metastatic CRPC", "US 2022: mHSPC with docetaxel (ARASENS)", "US 2025: mHSPC with ADT alone (ARANOTE)" ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-nmcrpc/>, <https://onco.cc/cancers/prostate-mhspc/> ;
  onco:technologies <https://onco.cc/technologies/androgen-deprivation/> ;
  onco:targets <https://onco.cc/targets/androgen-receptor/> ;
  onco:companies <https://onco.cc/companies/bayer/> ;
  onco:pathways <https://onco.cc/pathways/ar-signaling/> ;
  onco:terms <https://onco.cc/terms/mcrpc-mhspc/>, <https://onco.cc/terms/prostate-uk-drug-approvals/> ;
  onco:trials <https://onco.cc/trials/arasens/>, <https://onco.cc/trials/nct07611110/>, <https://onco.cc/trials/nct05794906/>, <https://onco.cc/trials/nct06785636/>, <https://onco.cc/trials/nct05367440/>, <https://onco.cc/trials/nct07450599/>, <https://onco.cc/trials/nct06568094/>, <https://onco.cc/trials/nct06190899/>, <https://onco.cc/trials/nct07190300/>, <https://onco.cc/trials/nct04464226/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-aramis-nejm-2019/> .