# OnCo record ddr (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/ddr/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "ddr" ;
  schema:name "DNA damage response & homologous recombination"@en ;
  schema:description "The DNA damage response is the cell's set of repair crews. Single-strand breaks are patched by PARP; double-strand breaks by BRCA-dependent homologous recombination. Lose one crew and the cell survives; lose both and it dies. That is how PARP inhibitors work."@en ;
  schema:url <https://onco.cc/pathways/ddr/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/DNA_repair> ;
  owl:sameAs <http://www.wikidata.org/entity/Q210538> ;
  schema:citation <https://en.wikipedia.org/wiki/DNA_repair> ;
  onco:cancers <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/pancreatic/> ;
  onco:technologies <https://onco.cc/technologies/parp-inhibitor/>, <https://onco.cc/technologies/hrd-testing/>, <https://onco.cc/technologies/synthetic-lethality-approaches/>, <https://onco.cc/technologies/platinum/>, <https://onco.cc/technologies/parp-pet/> ;
  onco:targets <https://onco.cc/targets/parp/>, <https://onco.cc/targets/brca/>, <https://onco.cc/targets/atr/>, <https://onco.cc/targets/wee1/>, <https://onco.cc/targets/tp53/> ;
  onco:drugs <https://onco.cc/drugs/olaparib/>, <https://onco.cc/drugs/niraparib/>, <https://onco.cc/drugs/talazoparib/>, <https://onco.cc/drugs/carboplatin/> .