# OnCo record de-escalation (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/de-escalation/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "de-escalation" ;
  schema:name "De-escalation, escalation and response-adapted therapy"@en ;
  schema:alternateName "de-escalation"@en, "de-escalate"@en, "de-escalated"@en, "de-escalating"@en, "de-intensification"@en, "de-intensify"@en, "treatment de-escalation"@en, "treatment intensification"@en, "intensification"@en, "response-adapted"@en, "response-guided"@en, "risk-adapted"@en, "risk-adapted therapy"@en, "biomarker-guided"@en, "ctDNA-guided"@en, "MRD-guided"@en, "PET-adapted"@en, "omission of chemotherapy"@en, "chemotherapy omission"@en, "chemotherapy-free"@en, "chemo-free"@en, "less is more"@en, "treatment omission"@en ;
  schema:description "Giving less treatment to patients who are doing well and more to those who are not, using a marker such as scan response, ctDNA or MRD to decide. The aim is to cure the same number of people with less harm."@en ;
  schema:url <https://onco.cc/terms/de-escalation/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT03036488>, <https://clinicaltrials.gov/study/NCT02743494> ;
  onco:related <https://onco.cc/terms/non-inferiority/>, <https://onco.cc/terms/deauville/>, <https://onco.cc/terms/umrd/>, <https://onco.cc/terms/ctdna/>, <https://onco.cc/terms/organ-preservation/> ;
  onco:sections <https://onco.cc/fronts/chemotherapy/> ;
  onco:trials <https://onco.cc/trials/dynamic/>, <https://onco.cc/trials/circulate-japan/>, <https://onco.cc/trials/keynote-522/>, <https://onco.cc/trials/checkmate-577/> .