# OnCo record destiny-breast03 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/destiny-breast03/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "destiny-breast03", "NCT03529110" ;
  schema:name "DESTINY-Breast03"@en ;
  schema:description "The head-to-head ADC trial where Enhertu beat Kadcyla by a wide margin, showing that payload and bystander effect matter."@en ;
  schema:url <https://onco.cc/trials/destiny-breast03/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT03529110> ;
  onco:status "positive" ;
  onco:phase "3" ;
  schema:startDate "2018-08-09" ;
  onco:cancers <https://onco.cc/cancers/breast-her2-positive/> ;
  onco:technologies <https://onco.cc/technologies/adc/>, <https://onco.cc/technologies/topoisomerase-inhibitors/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab-deruxtecan/>, <https://onco.cc/drugs/trastuzumab-emtansine/> ;
  onco:companies <https://onco.cc/companies/daiichi-sankyo/>, <https://onco.cc/companies/astrazeneca/> ;
  onco:people <https://onco.cc/people/ian-krop/>, <https://onco.cc/people/javier-cortes/>, <https://onco.cc/people/sara-hurvitz/>, <https://onco.cc/people/kim-sung-bae/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-destiny-breast03-nejm-2022/>, <https://onco.cc/key-papers/paper-destiny-breast03-lancet-2023-update/> .