# OnCo record destiny-pantumor02 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/destiny-pantumor02/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "destiny-pantumor02", "NCT04482309" ;
  schema:name "DESTINY-PanTumor02"@en ;
  schema:description "DESTINY-PanTumor02 gave the HER2-directed antibody-drug conjugate Enhertu to 267 patients in seven cohorts of HER2-expressing solid tumours, endometrial and cervical cancer among them. Endometrial cancer responded best, and in April 2024 the FDA granted the first tumour-agnostic HER2 approval, for tumours with the strongest HER2 staining and no satisfactory alternative."@en ;
  schema:url <https://onco.cc/trials/destiny-pantumor02/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT04482309>, <https://ascopubs.org/doi/10.1200/JCO.23.02005>, <https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22ENHERTU%22> ;
  onco:status "positive" ;
  onco:phase "2" ;
  schema:startDate "2020-08-18" ;
  onco:cancers <https://onco.cc/cancers/endometrial/>, <https://onco.cc/cancers/cervical/>, <https://onco.cc/cancers/endometrial-p53-abnormal/>, <https://onco.cc/cancers/uterine-carcinosarcoma/>, <https://onco.cc/cancers/recurrent-metastatic-cervical-cancer/>, <https://onco.cc/cancers/gallbladder/>, <https://onco.cc/cancers/cholangiocarcinoma/>, <https://onco.cc/cancers/biliary-tract-cancer/> ;
  onco:technologies <https://onco.cc/technologies/adc/>, <https://onco.cc/technologies/topoisomerase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/her2/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab-deruxtecan/> ;
  onco:companies <https://onco.cc/companies/astrazeneca/>, <https://onco.cc/companies/daiichi-sankyo/> ;
  onco:terms <https://onco.cc/terms/tumour-agnostic/> ;
  onco:people <https://onco.cc/people/funda-meric-bernstam/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-oh-destiny-pantumor02-biliary-pancreatic-esmo-open-2026/> .