# OnCo record determine-arm04 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/determine-arm04/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "determine-arm04", "NCT05786716" ;
  schema:name "DETERMINE arm 04: trastuzumab with pertuzumab in HER2-amplified or mutated rare cancers"@en ;
  schema:alternateName "DETERMINE"@en ;
  schema:description "DETERMINE is the UK platform that gives existing targeted drugs to people whose rare cancer carries the matching gene change. Its trastuzumab and pertuzumab arm is open to HER2-amplified gallbladder cancer at 27 NHS hospitals, with response and durable benefit as the endpoints."@en ;
  schema:url <https://onco.cc/trials/determine-arm04/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT05786716> ;
  onco:status "recruiting" ;
  onco:phase "2/3" ;
  onco:cancers <https://onco.cc/cancers/gallbladder/>, <https://onco.cc/terms/rare-cancers/> ;
  onco:technologies <https://onco.cc/technologies/monoclonal-antibody/>, <https://onco.cc/technologies/cgp/> ;
  onco:targets <https://onco.cc/targets/her2/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab/>, <https://onco.cc/drugs/pertuzumab/> ;
  onco:institutions <https://onco.cc/institutions/cruk/> ;
  onco:terms <https://onco.cc/terms/basket-umbrella-platform/>, <https://onco.cc/terms/master-protocol/>, <https://onco.cc/terms/tumour-agnostic/> .