# OnCo record determine-trial (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/determine-trial/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "determine-trial", "NCT05722886" ;
  schema:name "DETERMINE"@en ;
  schema:alternateName "DETERMINE trial"@en, "Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications using a National Evaluation Platform Trial"@en ;
  schema:description "DETERMINE is the United Kingdom's version of TAPUR: people with rare cancers whose tumours carry a change that an already licensed drug targets in another cancer receive that drug through the NHS in a trial, and if a group does well the results are designed to go straight to the bodies that decide NHS funding."@en ;
  schema:url <https://onco.cc/trials/determine-trial/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT05722886> ;
  onco:status "recruiting" ;
  onco:phase "platform" ;
  schema:startDate "2023-03-01" ;
  onco:cancers <https://onco.cc/terms/rare-cancers/>, <https://onco.cc/cancers/rare-childhood-cancers/> ;
  onco:technologies <https://onco.cc/technologies/cgp/>, <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:drugs <https://onco.cc/drugs/alectinib/>, <https://onco.cc/drugs/atezolizumab/>, <https://onco.cc/drugs/entrectinib/>, <https://onco.cc/drugs/trastuzumab/>, <https://onco.cc/drugs/pertuzumab/>, <https://onco.cc/drugs/vemurafenib/>, <https://onco.cc/drugs/cobimetinib/>, <https://onco.cc/drugs/vismodegib/> ;
  onco:companies <https://onco.cc/companies/roche-genentech/>, <https://onco.cc/companies/novartis/> ;
  onco:institutions <https://onco.cc/institutions/the-christie/>, <https://onco.cc/institutions/cruk-manchester-institute/>, <https://onco.cc/institutions/cruk/> ;
  onco:terms <https://onco.cc/terms/master-protocol/>, <https://onco.cc/terms/basket-umbrella-platform/>, <https://onco.cc/terms/tumour-agnostic/> ;
  onco:trials <https://onco.cc/trials/target-national/>, <https://onco.cc/trials/tapur/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-rare-cancers/> .