# OnCo record dhfr (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/dhfr/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "dhfr" ;
  schema:name "Dihydrofolate reductase (DHFR)"@en ;
  schema:description "The enzyme that recycles folate so cells can build DNA. Methotrexate blocks it, which is why folinic acid rescue after high-dose methotrexate matters."@en ;
  schema:url <https://onco.cc/targets/dhfr/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Dihydrofolate_reductase>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2861>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000228716>, <https://www.uniprot.org/uniprotkb/P00374/entry>, <https://www.ncbi.nlm.nih.gov/gene/1719> ;
  schema:citation <https://www.uniprot.org/uniprotkb/P00374/entry> ;
  schema:alternateName "DHFR" ;
  onco:targetClass "enzyme" ;
  onco:firstDescribed "1983"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/all-leukemia/>, <https://onco.cc/cancers/osteosarcoma/>, <https://onco.cc/cancers/primary-cns-lymphoma/> ;
  onco:drugs <https://onco.cc/drugs/methotrexate/>, <https://onco.cc/drugs/pemetrexed/> .