# OnCo record dhodh (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/dhodh/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "dhodh" ;
  schema:name "DHODH"@en ;
  schema:alternateName "dihydroorotate dehydrogenase"@en, "DHODH" ;
  schema:description "DHODH is an enzyme cells need to make pyrimidines, the building blocks of DNA and RNA. Blocking it pushed immature leukaemia cells to mature in mouse studies, and a DHODH inhibitor is in an early trial in solid tumours and lymphoma."@en ;
  schema:url <https://onco.cc/targets/dhodh/> ;
  schema:dateModified "2026-11-03"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2867>, <https://www.uniprot.org/uniprotkb/Q02127/entry>, <https://www.ncbi.nlm.nih.gov/gene/1723>, <https://doi.org/10.1016/j.cell.2016.08.057> ;
  onco:tag "pipeline-gap-target" ;
  onco:targetClass "enzyme" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2867>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000102967>, <https://www.uniprot.org/uniprotkb/Q02127/entry>, <https://www.ncbi.nlm.nih.gov/gene/1723> ;
  onco:cancers <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:drugs <https://onco.cc/drugs/jbz-001/> .