# OnCo record dna-replication-licensing (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/dna-replication-licensing/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "dna-replication-licensing" ;
  schema:name "DNA replication & origin licensing"@en ;
  schema:description "Before a cell divides it must copy three billion letters of DNA exactly once, 'licensing' thousands of start points in advance and firing them in waves. Cancers driven by MYC, cyclin E or RAS fire excess start points too fast, and antimetabolites such as 5-FU, topoisomerase poisons such as irinotecan and platinum drugs all jam this copying machinery."@en ;
  schema:url <https://onco.cc/pathways/dna-replication-licensing/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Eukaryotic_DNA_replication> ;
  schema:citation <https://doi.org/10.1146/annurev.biochem.71.110601.135425> ;
  onco:tag "mechanism", "mechanics-atlas" ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/topoisomerase-inhibitors/>, <https://onco.cc/technologies/platinum/>, <https://onco.cc/technologies/adc/> ;
  onco:targets <https://onco.cc/targets/kras/>, <https://onco.cc/targets/cdk4-6/>, <https://onco.cc/targets/atr/>, <https://onco.cc/targets/trop2/>, <https://onco.cc/targets/her2/> ;
  onco:drugs <https://onco.cc/drugs/gemcitabine/>, <https://onco.cc/drugs/fluorouracil/>, <https://onco.cc/drugs/methotrexate/>, <https://onco.cc/drugs/pemetrexed/>, <https://onco.cc/drugs/hydroxyurea/>, <https://onco.cc/drugs/irinotecan/>, <https://onco.cc/drugs/topotecan/>, <https://onco.cc/drugs/trastuzumab-deruxtecan/>, <https://onco.cc/drugs/sacituzumab-govitecan/> ;
  onco:pathways <https://onco.cc/pathways/replication-stress/>, <https://onco.cc/pathways/cell-cycle-engine-cdks/>, <https://onco.cc/pathways/ddr/>, <https://onco.cc/pathways/myc/> ;
  onco:terms <https://onco.cc/terms/topoisomerase-i-payloads/>, <https://onco.cc/terms/sn-38/>, <https://onco.cc/terms/dxd/>, <https://onco.cc/terms/exatecan/>, <https://onco.cc/terms/payload/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-bell-annu-rev-biochem/> .