# OnCo record dnmt1 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/dnmt1/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "dnmt1" ;
  schema:name "DNMT1 (DNA methyltransferase 1)"@en ;
  schema:description "The enzyme that copies methylation marks onto newly made DNA, keeping genes silenced. Azacitidine and decitabine trap and destroy it, waking silenced tumour suppressor genes in blood cancers."@en ;
  schema:url <https://onco.cc/targets/dnmt1/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/DNMT1>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2976>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000130816>, <https://www.uniprot.org/uniprotkb/P26358/entry>, <https://www.ncbi.nlm.nih.gov/gene/1786> ;
  schema:citation <https://www.uniprot.org/uniprotkb/P26358/entry> ;
  schema:alternateName "DNMT1" ;
  onco:targetClass "enzyme" ;
  onco:firstDescribed "1992"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/mds/>, <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/cmml/> ;
  onco:drugs <https://onco.cc/drugs/azacitidine/>, <https://onco.cc/drugs/decitabine/> .