# OnCo record dnmt3a (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/dnmt3a/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "dnmt3a" ;
  schema:name "DNA methyltransferase 3A (DNMT3A)"@en ;
  schema:description "DNMT3A writes new methyl marks on DNA; it is one of the most commonly mutated genes in acute myeloid leukaemia and is trapped by the hypomethylating drugs azacitidine and decitabine."@en ;
  schema:url <https://onco.cc/targets/dnmt3a/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/DNMT3A>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2978>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000119772>, <https://www.uniprot.org/uniprotkb/Q9Y6K1/entry>, <https://www.ncbi.nlm.nih.gov/gene/1788> ;
  schema:citation <https://www.uniprot.org/uniprotkb/Q9Y6K1/entry>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2978>, <https://www.ebi.ac.uk/chembl/explore/target/CHEMBL1992>, <https://doi.org/10.1038/ng.2872>, <https://doi.org/10.1038/ng.2873> ;
  schema:alternateName "DNMT3A" ;
  onco:targetClass "enzyme" ;
  onco:firstDescribed "1999"^^xsd:gYear ;
  onco:related <https://onco.cc/targets/dnmt1/> ;
  onco:cancers <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/mds/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:drugs <https://onco.cc/drugs/azacitidine/>, <https://onco.cc/drugs/decitabine/> ;
  onco:pathways <https://onco.cc/pathways/epigenetic-reprogramming/>, <https://onco.cc/pathways/clonal-haematopoiesis/> .