# OnCo record dose-escalation-design (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/dose-escalation-design/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "dose-escalation-design" ;
  schema:name "Dose-escalation designs (3+3, BOIN, dose-expansion)"@en ;
  schema:alternateName "3+3"@en, "3 + 3"@en, "3+3 design"@en, "rule-based design"@en, "BOIN"@en, "Bayesian optimal interval"@en, "CRM"@en, "continual reassessment method"@en, "mTPI"@en, "TITE-CRM"@en, "model-based dose finding"@en, "model-based design"@en, "dose-finding"@en, "dose finding"@en, "dose-finding study"@en, "dose escalation cohort"@en, "dose escalation"@en, "dose-escalation"@en, "dose escalation phase"@en, "dose-expansion"@en, "dose expansion"@en, "expansion phase"@en, "accelerated titration"@en, "backfill cohort"@en, "dose level"@en, "dose levels"@en, "cohort of 3"@en, "backfill cohorts"@en, "model-based designs"@en ;
  schema:description "How a phase 1 trial climbs from a tiny starting dose to a useful one: the old 3+3 design treats three patients at a time and moves up if none has serious toxicity; newer statistical designs (BOIN, CRM) use all the data to pick doses more accurately with fewer patients on ineffective levels."@en ;
  schema:url <https://onco.cc/terms/dose-escalation-design/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Phase_I_clinical_trial#Dose_escalation> ;
  schema:citation <https://en.wikipedia.org/wiki/Phase_I_clinical_trial#Dose_escalation> ;
  onco:related <https://onco.cc/terms/dose-limiting-toxicity/>, <https://onco.cc/terms/mtd/>, <https://onco.cc/terms/rp2d/>, <https://onco.cc/terms/first-in-human/>, <https://onco.cc/terms/project-optimus/>, <https://onco.cc/terms/bayesian-trial-design/>, <https://onco.cc/terms/seamless-adaptive/>, <https://onco.cc/terms/trial-phases/> ;
  onco:sections <https://onco.cc/fronts/drug-discovery/> ;
  onco:technologies <https://onco.cc/terms/project-optimus/> ;
  onco:trials <https://onco.cc/trials/rejoice-ovarian01/>, <https://onco.cc/trials/low-dose-nivolumab-tmh/> .