# OnCo record dose-limiting-toxicity (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/dose-limiting-toxicity/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "dose-limiting-toxicity" ;
  schema:name "Dose-limiting toxicity (DLT)"@en ;
  schema:alternateName "DLT"@en, "DLTs"@en, "dose-limiting"@en, "dose limiting toxicity"@en, "dose-limiting toxicities"@en, "DLT period"@en, "DLT window"@en, "no DLTs"@en, "DLT rate"@en ;
  schema:description "A side effect in an early trial severe enough (usually grade 3 or worse, or forcing a long treatment pause) that the dose cannot safely go higher. Counting DLTs at each dose level is how phase 1 trials find the maximum tolerated dose."@en ;
  schema:url <https://onco.cc/terms/dose-limiting-toxicity/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:citation <https://www.cancer.gov/publications/dictionaries/cancer-terms/def/dose-limiting> ;
  onco:related <https://onco.cc/terms/mtd/>, <https://onco.cc/terms/rp2d/>, <https://onco.cc/terms/dose-escalation-design/>, <https://onco.cc/terms/ctcae-grading/> ;
  onco:sections <https://onco.cc/fronts/drug-discovery/> ;
  onco:technologies <https://onco.cc/terms/project-optimus/> .