# OnCo record dose-modification (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/dose-modification/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "dose-modification" ;
  schema:name "Dose reduction, interruption and discontinuation"@en ;
  schema:alternateName "dose reduction"@en, "dose reductions"@en, "dose-reduction"@en, "dose reduced"@en, "dose interruption"@en, "dose interruptions"@en, "dose delay"@en, "dose delays"@en, "treatment delay"@en, "dose hold"@en, "hold treatment"@en, "dose modification"@en, "dose modifications"@en, "dose adjustment"@en, "dose adjustments"@en, "discontinuation"@en, "discontinuations"@en, "discontinued"@en, "treatment discontinuation"@en, "discontinuation rate"@en, "discontinuation due to adverse events"@en, "permanent discontinuation"@en, "stopped treatment"@en, "treatment cessation"@en, "relative dose intensity"@en, "RDI"@en, "adherence"@en, "non-adherence"@en, "compliance"@en, "real-world dosing"@en, "starting dose"@en, "dose holds"@en, "treatment delays"@en ;
  schema:description "The everyday tools for living with side effects: pausing a drug until a problem settles (interruption), restarting at a lower dose (reduction), or stopping it for good (discontinuation). Between 30 and 60% of patients on oral targeted drugs need a reduction, so these rates are the clearest test of whether a dose was set right."@en ;
  schema:url <https://onco.cc/terms/dose-modification/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Dose_(biochemistry)> ;
  schema:citation <https://en.wikipedia.org/wiki/Dose_(biochemistry)> ;
  onco:related <https://onco.cc/terms/ctcae-grading/>, <https://onco.cc/terms/mtd/>, <https://onco.cc/terms/therapeutic-index/>, <https://onco.cc/terms/pharmacokinetics/>, <https://onco.cc/terms/qol-pro/> ;
  onco:sections <https://onco.cc/fronts/supportive-care/> ;
  onco:technologies <https://onco.cc/terms/project-optimus/> .