# OnCo record double-hit-lymphoma (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/double-hit-lymphoma/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "double-hit-lymphoma" ;
  schema:name "Double-hit / high-grade B-cell lymphoma"@en ;
  schema:description "Double-hit lymphoma is a large B-cell lymphoma with rearrangements of two oncogenes (MYC plus BCL2 and/or BCL6), which behaves aggressively and often escapes R-CHOP."@en ;
  schema:url <https://onco.cc/terms/double-hit-lymphoma/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Diffuse_large_B-cell_lymphoma> ;
  schema:citation <https://www.cancer.gov/publications/dictionaries/cancer-terms/def/double-hit-lymphoma>, <https://doi.org/10.1182/blood-2012-06-435842>, <https://doi.org/10.1200/JCO.2011.41.0985>, <https://doi.org/10.1073/pnas.79.24.7824>, <https://doi.org/10.1038/s41375-022-01620-2> ;
  onco:cancers <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/burkitt-lymphoma/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:targets <https://onco.cc/targets/bcl2/>, <https://onco.cc/targets/myc-gene/>, <https://onco.cc/targets/bcl6/> ;
  onco:pathways <https://onco.cc/pathways/myc/>, <https://onco.cc/pathways/apoptosis-bcl2/> .