# OnCo record double-hit-rearrangement (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/double-hit-rearrangement/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "double-hit-rearrangement" ;
  schema:name "Double-hit and triple-hit: MYC with BCL2 and BCL6 rearrangement"@en ;
  schema:alternateName "Double hit lymphoma"@en, "Triple hit lymphoma"@en, "DHL"@en, "HGBL-DH"@en, "high-grade B-cell lymphoma with MYC and BCL2 rearrangements"@en, "MYC rearrangement FISH"@en ;
  schema:description "A lymphoma that carries a rearrangement of MYC, the gene that drives growth, together with one of BCL2 or BCL6, the genes that stop a cell dying. Having both is far worse than having either, and it usually means a stronger treatment than standard R-CHOP."@en ;
  schema:url <https://onco.cc/biomarkers/double-hit-rearrangement/> ;
  schema:dateModified "2026-09-30"^^xsd:date ;
  schema:citation <https://doi.org/10.1073/pnas.79.24.7824>, <https://doi.org/10.1182/blood-2012-06-435842>, <https://doi.org/10.1038/s41375-022-01620-2> ;
  onco:tag "biomarker", "lymphoma" ;
  onco:related <https://onco.cc/biomarkers/bcl2-rearrangement/>, <https://onco.cc/biomarkers/myc-bcl2-double-expressor/> ;
  onco:cancers <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/burkitt-lymphoma/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:technologies <https://onco.cc/technologies/cytogenetics-fish/> ;
  onco:targets <https://onco.cc/targets/myc-gene/>, <https://onco.cc/targets/bcl2/>, <https://onco.cc/targets/bcl6/> ;
  onco:pathways <https://onco.cc/pathways/myc/>, <https://onco.cc/pathways/apoptosis-bcl2/>, <https://onco.cc/pathways/germinal-centre-reaction/> ;
  onco:terms <https://onco.cc/terms/fish/>, <https://onco.cc/terms/cytogenetics/>, <https://onco.cc/terms/lymphoma-tx-cns-prophylaxis/>, <https://onco.cc/terms/lymphoma-bio-germinal-centre/> .