# OnCo record downstream-purification-chromatography (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/downstream-purification-chromatography/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "downstream-purification-chromatography" ;
  schema:name "Downstream purification (Protein A capture, viral clearance, polishing)"@en ;
  schema:description "After hamster cells have grown an antibody drug, the antibody has to be fished out of a soup of cells, DNA and viruses and made pure enough to inject. Purification is where much of the cost and many of the bottlenecks of biologics sit."@en ;
  schema:url <https://onco.cc/technologies/downstream-purification-chromatography/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://www.ich.org/page/quality-guidelines>, <https://en.wikipedia.org/wiki/Protein_A> ;
  onco:status "standard-of-care" ;
  onco:tag "manufacturing-wave" ;
  onco:sections <https://onco.cc/fronts/immunotherapy/>, <https://onco.cc/fronts/adcs/> ;
  onco:technologies <https://onco.cc/technologies/monoclonal-antibody-manufacturing/>, <https://onco.cc/technologies/single-use-bioprocessing/>, <https://onco.cc/technologies/sterile-fill-finish/>, <https://onco.cc/technologies/adc-cdmo-manufacturing/>, <https://onco.cc/technologies/biosimilar-manufacturing/>, <https://onco.cc/technologies/monoclonal-antibody/>, <https://onco.cc/technologies/bispecific-antibody/> ;
  onco:drugs <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/drugs/nivolumab/>, <https://onco.cc/drugs/trastuzumab/>, <https://onco.cc/drugs/rituximab/>, <https://onco.cc/drugs/bevacizumab/> ;
  onco:companies <https://onco.cc/companies/cytiva/>, <https://onco.cc/companies/sartorius/>, <https://onco.cc/companies/thermo-fisher/>, <https://onco.cc/companies/merck-kgaa/>, <https://onco.cc/companies/samsung-biologics/>, <https://onco.cc/companies/lonza/>, <https://onco.cc/companies/wuxi-biologics/>, <https://onco.cc/companies/fujifilm-diosynth/>, <https://onco.cc/companies/boehringer-ingelheim-biox/> .