# OnCo record downstream (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/downstream/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "downstream" ;
  schema:name "Downstream and upstream"@en ;
  schema:alternateName "downstream"@en, "upstream"@en, "downstream of"@en, "upstream of"@en, "downstream signalling"@en, "downstream signaling"@en, "downstream effector"@en, "downstream effectors"@en, "downstream target"@en, "downstream targets"@en ;
  schema:description "Position in a signalling chain: upstream proteins send the message, downstream proteins receive it. A mutation downstream of a drug's target can make the drug useless."@en ;
  schema:url <https://onco.cc/terms/downstream/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Signal_transduction> ;
  owl:sameAs <http://www.wikidata.org/entity/Q828130> ;
  schema:citation <https://en.wikipedia.org/wiki/Signal_transduction> ;
  onco:related <https://onco.cc/terms/signalling-pathway/>, <https://onco.cc/terms/growth-signal/>, <https://onco.cc/terms/kinase/>, <https://onco.cc/terms/resistance/> ;
  onco:targets <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/kras/>, <https://onco.cc/targets/braf/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/>, <https://onco.cc/pathways/pi3k-akt-mtor/> .