# OnCo record doxorubicin-cardio-caution (pairing). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pairings/doxorubicin-cardio-caution/>
  a schema:MedicalTherapy ;
  onco:kind "pairing" ;
  schema:identifier "doxorubicin-cardio-caution" ;
  schema:name "Caution: cumulative anthracycline dose and the heart"@en ;
  schema:description "Every dose of doxorubicin adds to a lifetime total; above roughly 450 mg/m2 heart failure risk rises steeply, so sarcoma and lymphoma regimens are capped and hearts are monitored."@en ;
  schema:url <https://onco.cc/pairings/doxorubicin-cardio-caution/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://doi.org/10.1002/cncr.11407> ;
  onco:cancers <https://onco.cc/cancers/sarcoma/>, <https://onco.cc/cancers/hodgkin-lymphoma/>, <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/tnbc/> ;
  onco:technologies <https://onco.cc/technologies/cardio-oncology/> ;
  onco:drugs <https://onco.cc/drugs/doxorubicin/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-swain-cancer/> ;
  onco:pairs <https://onco.cc/drugs/doxorubicin/>, <https://onco.cc/technologies/cardio-oncology/> .