# OnCo record dpyd-genotyping (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/dpyd-genotyping/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "dpyd-genotyping" ;
  schema:name "DPYD genotyping and DPD phenotyping before fluoropyrimidines"@en ;
  schema:alternateName "DPYD testing"@en, "DPD deficiency testing"@en, "dihydropyrimidine dehydrogenase test"@en, "uracil phenotyping"@en, "DPYD*2A"@en ;
  schema:description "A one-off blood test done before fluorouracil or capecitabine that finds the roughly one in twenty-five people who cannot break the drug down; halving their dose prevents severe and occasionally fatal toxicity without losing effect."@en ;
  schema:url <https://onco.cc/technologies/dpyd-genotyping/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/S1470-2045(18)30686-7>, <https://cpicpgx.org/guidelines/guideline-for-fluoropyrimidines-and-dpyd/>, <https://www.ema.europa.eu/en/news/ema-recommendations-dpd-testing-prior-treatment-fluorouracil-capecitabine-tegafur-and-flucytosine> ;
  onco:status "standard-of-care" ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/gastric/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/breast-cancer/>, <https://onco.cc/cancers/head-and-neck/>, <https://onco.cc/cancers/anal/>, <https://onco.cc/cancers/oesophageal-adenocarcinoma/> ;
  onco:sections <https://onco.cc/fronts/diagnostics/>, <https://onco.cc/fronts/chemotherapy/>, <https://onco.cc/fronts/supportive-care/> ;
  onco:technologies <https://onco.cc/technologies/oncology-pharmacogenomics/>, <https://onco.cc/technologies/germline-testing/>, <https://onco.cc/technologies/ugt1a1-genotyping/>, <https://onco.cc/technologies/tpmt-nudt15-genotyping/> ;
  onco:drugs <https://onco.cc/drugs/fluorouracil/>, <https://onco.cc/drugs/capecitabine/> ;
  onco:institutions <https://onco.cc/institutions/ema/> ;
  onco:terms <https://onco.cc/terms/dose-modification/>, <https://onco.cc/terms/hand-foot-syndrome/>, <https://onco.cc/terms/mucositis/>, <https://onco.cc/terms/neutropenia/>, <https://onco.cc/terms/pharmacokinetics/> .