# OnCo record dpyd-testing-before-fluoropyrimidines (protocol). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/protocols/dpyd-testing-before-fluoropyrimidines/>
  a schema:MedicalGuideline ;
  onco:kind "protocol" ;
  schema:identifier "dpyd-testing-before-fluoropyrimidines" ;
  schema:name "DPD deficiency testing before fluorouracil, capecitabine or tegafur, and dosing by the result"@en ;
  schema:alternateName "DPYD test"@en, "DPD test"@en, "DPYD genotyping before chemotherapy"@en, "uracil test before capecitabine"@en, "DPD deficiency screening"@en, "fluoropyrimidine pharmacogenetic testing"@en, "DPYD activity score dosing"@en ;
  schema:description "Before your first dose of fluorouracil (5-FU) given into a vein, capecitabine tablets or tegafur, you should have a blood test for DPD deficiency. A few people break these drugs down very slowly, and a normal dose can make them seriously ill. If the test finds this, the dose is lowered or a different drug is chosen. A normal result does not rule out side effects, so still report them quickly."@en ;
  schema:url <https://onco.cc/protocols/dpyd-testing-before-fluoropyrimidines/> ;
  schema:dateModified "2026-11-11"^^xsd:date ;
  onco:technologies <https://onco.cc/technologies/dpyd-genotyping/>, <https://onco.cc/technologies/oncology-pharmacogenomics/>, <https://onco.cc/technologies/fluorouracil-pharmacokinetic-dosing/> ;
  onco:targets <https://onco.cc/targets/dpyd/> ;
  onco:drugs <https://onco.cc/drugs/fluorouracil/>, <https://onco.cc/drugs/capecitabine/>, <https://onco.cc/drugs/tegafur-gimeracil-oteracil/>, <https://onco.cc/drugs/uridine-triacetate/> ;
  onco:terms <https://onco.cc/terms/pharmacogenomics-term/>, <https://onco.cc/terms/dose-modification/>, <https://onco.cc/terms/neutropenia/>, <https://onco.cc/terms/mucositis/>, <https://onco.cc/terms/chemotherapy-side-effects-colorectal/>, <https://onco.cc/terms/chemotherapy-side-effects-pancreatic/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-henricks-lancet-oncol/> .