# OnCo record driver-mutation (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/driver-mutation/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "driver-mutation" ;
  schema:name "Driver mutation"@en ;
  schema:alternateName "driver mutations"@en, "driver"@en, "drivers"@en, "oncogenic driver"@en, "oncogenic drivers"@en, "driver alteration"@en, "driver alterations"@en, "driver gene"@en, "driver genes"@en, "passenger mutation"@en, "passenger mutations"@en, "driver mutation"@en, "oncogene-driven"@en, "driver-positive"@en, "driver-negative"@en, "actionable"@en, "actionable mutation"@en, "actionable alteration"@en, "targetable"@en, "targetable driver"@en, "targetable mutation"@en, "molecularly selected"@en, "biomarker-driven"@en, "actionable alterations"@en, "targetable drivers"@en, "targetable mutations"@en, "driver-mutation-term"@en ;
  schema:description "One of the few mutations in a tumour that actually causes it to grow. Everything else is a passenger along for the ride. Drivers are the mutations drugs are aimed at."@en ;
  schema:url <https://onco.cc/terms/driver-mutation/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Carcinogenesis#Driver_and_passenger_mutations> ;
  owl:sameAs <http://www.wikidata.org/entity/Q1637543> ;
  schema:citation <https://en.wikipedia.org/wiki/Carcinogenesis#Driver_and_passenger_mutations> ;
  onco:related <https://onco.cc/terms/mutation/>, <https://onco.cc/terms/oncogene/>, <https://onco.cc/terms/tumour-suppressor-gene/>, <https://onco.cc/terms/oncogene-addiction/>, <https://onco.cc/terms/genomic-profiling/>, <https://onco.cc/terms/targeted-therapy-term/>, <https://onco.cc/terms/egfr-mutation-subtypes/>, <https://onco.cc/terms/kras-mutation-subtypes/>, <https://onco.cc/terms/braf-v600-mutation/>, <https://onco.cc/terms/gene-fusion/>, <https://onco.cc/terms/tumour-agnostic/>, <https://onco.cc/terms/driver-passenger-model/>, <https://onco.cc/terms/somatic-mutation-theory/> ;
  onco:sections <https://onco.cc/fronts/targeted-therapy/>, <https://onco.cc/fronts/diagnostics/> ;
  onco:technologies <https://onco.cc/technologies/cgp/>, <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/companion-diagnostic/> ;
  onco:targets <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/kras/>, <https://onco.cc/targets/braf/>, <https://onco.cc/targets/alk/>, <https://onco.cc/targets/tp53/> .