# OnCo record driver-passenger-model (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/driver-passenger-model/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "driver-passenger-model" ;
  schema:name "Driver and passenger mutations: the refined somatic mutation theory"@en ;
  schema:alternateName "driver-passenger model"@en, "mountains and hills"@en, "cancer genome landscape"@en, "gatekeepers and caretakers"@en ;
  schema:description "When whole cancer genomes were read, tumours turned out to carry thousands of mutations, of which only a handful drive growth; the rest are passengers that happened to be in the cell. The refinement made the somatic mutation theory precise and testable, and it is the basis of genomic profiling and of matching drugs to mutations."@en ;
  schema:url <https://onco.cc/terms/driver-passenger-model/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Carcinogenesis#Driver_and_passenger_mutations> ;
  schema:citation <https://doi.org/10.1126/science.1235122>, <https://doi.org/10.1038/nature07943>, <https://doi.org/10.1038/386761a0>, <https://doi.org/10.1016/j.cell.2017.09.042>, <https://doi.org/10.1073/pnas.1213968110> ;
  onco:tag "theory" ;
  onco:related <https://onco.cc/pathways/theories-of-cancer/>, <https://onco.cc/terms/somatic-mutation-theory/>, <https://onco.cc/terms/clonal-evolution-theory/>, <https://onco.cc/terms/ageing-tissue-field-theory/>, <https://onco.cc/terms/driver-mutation/>, <https://onco.cc/terms/oncogene-addiction/>, <https://onco.cc/terms/mutational-signature/>, <https://onco.cc/terms/tmb/>, <https://onco.cc/terms/neoantigen/>, <https://onco.cc/pathways/oncogene-activation-two-hit/>, <https://onco.cc/pathways/mutagenesis-signatures/> ;
  onco:technologies <https://onco.cc/technologies/cgp/>, <https://onco.cc/technologies/wes-wgs/>, <https://onco.cc/technologies/companion-diagnostic/> ;
  onco:targets <https://onco.cc/targets/kras/>, <https://onco.cc/targets/braf/>, <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/tp53/> ;
  onco:drugs <https://onco.cc/drugs/larotrectinib/>, <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/drugs/osimertinib/> ;
  onco:pathways <https://onco.cc/pathways/oncogene-activation-two-hit/>, <https://onco.cc/pathways/mutagenesis-signatures/> ;
  onco:people <https://onco.cc/people/bert-vogelstein/>, <https://onco.cc/people/kenneth-kinzler/>, <https://onco.cc/people/michael-stratton/>, <https://onco.cc/people/serena-nik-zainal/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-vogelstein-cancer-genome-landscapes-science-2013/>, <https://onco.cc/key-papers/paper-martincorena-somatic-mutations-normal-skin-science-2015/>, <https://onco.cc/key-papers/paper-kinzler-nature/>, <https://onco.cc/key-papers/paper-martincorena-cell/>, <https://onco.cc/key-papers/paper-stratton-nature/>, <https://onco.cc/key-papers/paper-mcfarland-proc-natl-acad-sci-u-s-a/> .