# OnCo record drug-efflux-pumps (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/drug-efflux-pumps/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "drug-efflux-pumps" ;
  schema:name "Drug efflux pumps (ABC transporters)"@en ;
  schema:description "Cancer cells can install pumps in their outer membrane that throw chemotherapy back out as fast as it comes in. The same pumps guard the gut, brain and bone marrow in healthy tissue, which is why blocking them failed as a strategy and why drug designers now choose payloads the pumps cannot grip."@en ;
  schema:url <https://onco.cc/pathways/drug-efflux-pumps/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/P-glycoprotein> ;
  schema:citation <https://doi.org/10.1038/s41568-018-0005-8> ;
  onco:tag "mechanism", "mechanics-atlas" ;
  onco:technologies <https://onco.cc/technologies/adc/>, <https://onco.cc/technologies/radioligand-therapy/>, <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/topoisomerase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/trop2/>, <https://onco.cc/targets/her2/>, <https://onco.cc/targets/kras/>, <https://onco.cc/targets/alk/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab-deruxtecan/>, <https://onco.cc/drugs/datopotamab-deruxtecan/>, <https://onco.cc/drugs/sacituzumab-tirumotecan/>, <https://onco.cc/drugs/sacituzumab-govitecan/>, <https://onco.cc/drugs/enfortumab-vedotin/>, <https://onco.cc/drugs/paclitaxel/>, <https://onco.cc/drugs/doxorubicin/>, <https://onco.cc/drugs/lorlatinib/> ;
  onco:pathways <https://onco.cc/pathways/emt/>, <https://onco.cc/pathways/keap1-nrf2/>, <https://onco.cc/pathways/blood-brain-barrier-metastasis/>, <https://onco.cc/pathways/resistance-routes-map/>, <https://onco.cc/pathways/cancer-stem-cells-plasticity/> ;
  onco:terms <https://onco.cc/terms/efflux-pump/>, <https://onco.cc/terms/payload/>, <https://onco.cc/terms/dxd/>, <https://onco.cc/terms/exatecan/>, <https://onco.cc/terms/sn-38/>, <https://onco.cc/terms/mmae/>, <https://onco.cc/terms/bystander-effect/>, <https://onco.cc/terms/adc-sequencing/>, <https://onco.cc/terms/resistance/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-resistance/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-robey-nat-rev-cancer/> .